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Lysophospholipase D Polyclonal Antibody

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    Lyso<wbr/>phospholipase D Polyclonal Antibody
  • Lyso<wbr/>phospholipase D Polyclonal Antibody
Cat No: 10005375
Cayman

Lysophosphatidic acid (LPA) is an extracellular signaling lipid that evokes multiple biological functions including induction of platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and chemotaxis.{12477} Lysophosphol...

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: 1 ea

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • antibodies lyso-PLD ENPP-2 ICC WB LPA enzyme LPC lysophosphatidylcholine lysophosphatidic autotaxin ATX SDSPAGE LPA LysoPLD
Product Overview:
Lysophosphatidic acid (LPA) is an extracellular signaling lipid that evokes multiple biological functions including induction of platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and chemotaxis.{12477} Lysophospholipase D (lysoPLD) was first discovered in 1999 as the enzyme responsible for generating LPA from lysophosphatidylcholine (LPC).{13068} It was later revealed to be identical to an autocrine motility factor, autotaxin (ATX), which plays a role in tumor progression and metastasis.{13069,13071} LysoPLD/ATX mRNA is widely expressed with highest levels found in brain, ovary, lung, intestine, and testis.{13067,13070} Rat lysoPLD is composed of 885 amino acids with an estimated molecular weight of 101 kDa. The protein is reported to be heavily glycosylated and thus its apparent size on SDS-PAGE may be run as high as 125 kDa. Useful positive controls include cerebrospinal fluid, mouse ascites or seminal plasma.
Size 1 ea
Shipping dry ice
Host Rabbit
Antigen Peptide from the C-terminal region of rat lysoPLD
Application(s)

ICC, IHC, and WB

Formulation 500 µl of Peptide affinity-purified antibody
Custom Code 3822.19
UNSPSC code 12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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