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22-Oxacalcitriol

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    22-<wbr/>Oxacalcitriol
  • 22-<wbr/>Oxacalcitriol
Cat No: 10794
Biochemicals - Receptor Pharmacology
Cayman

Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, i...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol
Correlated keywords:
  • vitamins receptors agonists cancers psoriasis endocrinology nutrition D VDR PTH supress parathyroid hormones synthesis secretions hyperthyroidism renal failure 22 oxacalcitrol analogs calcitrol hypercalcemia inhibits inhibitors inhibition keratinocytes proliferation apoptosis tumors cells
Product Overview:
Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis.{22231,22230} First reported to avoid hypercalcemia, an undesirable side effect of calcitriol, prolonged treatment with 22-oxalcalcitriol can be calcemic in humans.{22231,22230} Analogs of calcitriol, including 22-oxacalcitriol, inhibit human keratinocyte proliferation while inducing differentiation and is beneficial in treating psoriasis.{22227,22226} 22-Oxacalcitriol also blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells.{22229}
Size 500 µg
Shipping dry ice
CAS Number 103909-75-7
Molecular Formula C26H42O4
SMILES O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@]3([H])[C@H](C)OCCC(C)(C)O)([H])[C@]3(C)CCC\2
Molecular Weight 418,6
Formulation A crystalline solid
Purity ≥95%
Custom Code 2936.29
UNSPSC code 12352100

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