22-Oxacalcitriol

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22-Oxacalcitriol

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Cat No: 10794

Biochemicals - Receptor Pharmacology

Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol

Correlated keywords:

vitamins receptors agonists cancers psoriasis endocrinology nutrition D VDR PTH supress parathyroid hormones synthesis secretions hyperthyroidism renal failure 22 oxacalcitrol analogs calcitrol hypercalcemia inhibits inhibitors inhibition keratinocytes proliferation apoptosis tumors cells

Product Overview:
Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis.{22231,22230} First reported to avoid hypercalcemia, an undesirable side effect of calcitriol, prolonged treatment with 22-oxalcalcitriol can be calcemic in humans.{22231,22230} Analogs of calcitriol, including 22-oxacalcitriol, inhibit human keratinocyte proliferation while inducing differentiation and is beneficial in treating psoriasis.{22227,22226} 22-Oxacalcitriol also blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells.{22229}

Size	500 µg
Shipping	dry ice
CAS Number	103909-75-7
Molecular Formula	C₂₆H₄₂O₄
SMILES	O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@]3([H])[C@H](C)OCCC(C)(C)O)([H])[C@]3(C)CCC\2
Molecular Weight	418,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2936.29
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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