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22-Oxacalcitriol

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    22-<wbr/>Oxacalcitriol
  • 22-<wbr/>Oxacalcitriol
Cat No: 10794
Biochemicals - Receptor Pharmacology
Cayman
€82.00
Price is excluding VAT and does not include packaging neither shipping

Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, i...

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 4-methylene-5Z-[2E-[(3aS)-octahydro-1S-[1S-(3-hydroxy-3-methylbutoxy)ethyl]-7aS-methyl-4H-inden-4-ylidene]ethylidene]-1R,3S-cyclohexanediol
Correlated keywords:
  • vitamins receptors agonists cancers psoriasis endocrinology nutrition D VDR PTH supress parathyroid hormones synthesis secretions hyperthyroidism renal failure 22 oxacalcitrol analogs calcitrol hypercalcemia inhibits inhibitors inhibition keratinocytes proliferation apoptosis tumors cells
Product Overview:
Agonists of the vitamin D receptor are used to suppress parathyroid hormone (PTH) synthesis and secretion in the treatment of hyperparathyroidism associated with renal failure.{21563} 22-Oxacalcitriol is an analog of calcitriol that, like calcitriol, is a receptor-active form of vitamin D3 which effectively blocks PTH synthesis.{22231,22230} First reported to avoid hypercalcemia, an undesirable side effect of calcitriol, prolonged treatment with 22-oxalcalcitriol can be calcemic in humans.{22231,22230} Analogs of calcitriol, including 22-oxacalcitriol, inhibit human keratinocyte proliferation while inducing differentiation and is beneficial in treating psoriasis.{22227,22226} 22-Oxacalcitriol also blocks the proliferation while inducing differentiation and apoptosis of certain tumor cells.{22229}
Size 500 µg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 103909-75-7
Molecular Formula C26H42O4
SMILES O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@]3([H])[C@H](C)OCCC(C)(C)O)([H])[C@]3(C)CCC\2
Molecular Weight 418,6
Formulation A crystalline solid
Purity ≥95%
Custom Code 2936.29
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cross selling for this product : 22-<wbr/>Oxacalcitriol There are 9 products.

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