4-hydroxy Nonenal Glutathione (trifluoroacetate salt)

Biochemicals - Ox Stress Reagents

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Cat No: 10627

Biochemicals - Ox Stress Reagents

4-hydroxy Nonenal Glutathione (HNE-GSH) is a major adduct formed by the reaction of 4-HNE with GSH.{18611,7334,18610,18731} 4-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.{18729} The trapping of 4-HN...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-?-glutamyl-S-[(3)-tetrahydro-5-hydroxy-2-pentyl-3-furanyl]-L-cysteinyl-glycine

Correlated keywords:

204851-41-2 oxidative stress lipids peroxidation 4-hydroxy nonenal 4-HNE GSH-HNE internal HNE-GSH MS glutathione-HNE glutathiones HNEs

Product Overview:
4-hydroxy Nonenal Glutathione (HNE-GSH) is a major adduct formed by the reaction of 4-HNE with GSH.{18611,7334,18610,18731} 4-HNE-GSH levels in liver, plasma, or isolated cells can serve as biomarkers for oxidative stress.{18729} The trapping of 4-HNE by glutathione to give HNE-GSH prevents the formation of DNA adducts with 4-HNE.{1670,18730} In human polymorphonuclear leukocytes, HNE-GSH is metabolized to 1,4-dihydroxynonene glutathione (DHN-GSH), 4-hydroxynonenoic acid glutathione (HNA-GSH), and 4-hydroxy nonenal mercapturic acid (HNE-MA).{18611}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₁₉H₃₃N₃O₈S • CF₃COOH
SMILES	O=C(NCC(O)=O)[C@@H](CSC1CC(O)OC1CCCCC)NC(CC[C@H](N)C(O)=O)=O.FC(F)(C(O)=O)F
Molecular Weight	577,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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