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(S)-Bromoenol lactone-d7

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    (S)-<wbr/>Bromoenol lactone-<wbr/>d<sub>7</sub>
  • (S)-<wbr/>Bromoenol lactone-<wbr/>d<sub>7</sub>
Cat No: 10535
Biochemicals - Isotopically Labeled Standards

(S)-Bromoenol lactone-d7 ((S)-BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of (S)-BEL by GC- or LC-mass spectrometry (MS). The phospholipases are...


This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
  • 6E-(bromoethylene)tetrahydro-3S-(1-naphthalenyl-2,3,4,5,6,7,8-d7)-2H-pyran-2-one
Correlated keywords:
  • selective iPLA2 inhibitors phospholipases PLAs BEL iPLA2b iPLA2.beta. iPLA2g iPLA2.gamma. lipids hydrolases cells signaling digestion membrane remodeling venom calcium independent releases AA arachidonic acids physiologic stimuli irreversible chiral mechanism-based vasopression-induced rat aortic smooth muscle A10 deuterium deuterateds GC/MS GC-MS LC/MS LC-MS mass spectrometry MS signalling standards
Product Overview:
(S)-Bromoenol lactone-d7 ((S)-BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of (S)-BEL by GC- or LC-mass spectrometry (MS). The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipase A2 (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2β that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 value of 2 µM.{12978} (S)-BEL is more than 1,000-fold selective for iPLA2 versus cPLA2, and is 10-fold selective for iPLA2β versus iPLA2γ.
Size 100 µg
Shipping dry ice
Molecular Formula C16H6BrD7O2
SMILES [2H]C1=C([2H])C([2H])=C2C(C([2H])=C([2H])C([2H])=C2[C@@]3([H])C(O/C(CC3)=C/Br)=O)=C1[2H]
Molecular Weight 324,2
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d7)
Custom Code 2932.20
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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