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(R)-Bromoenol lactone-d7

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    (R)-<wbr/>Bromoenol lactone-<wbr/>d<sub>7</sub>
  • (R)-<wbr/>Bromoenol lactone-<wbr/>d<sub>7</sub>
Cat No: 10534
Biochemicals - Isotopically Labeled Standards

(R)-Bromoenol lactone-d7 ((R)-BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of (R)-BEL by GC- or LC-mass spectrometry (MS). The phospholipases are...


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Territorial Availability: Available through Bertin Technologies only in France
  • 6E-(bromoethylene)tetrahydro-3R-(1-naphthalenyl-2,3,4,5,6,7,8-d7)-2H-pyran-2-one
Correlated keywords:
  • selective iPLA2 inhibitors phospholipases PLAs BEL iPLA2b iPLA2.beta. iPLA2g iPLA2.gamma. lipids hydrolases cells signaling digestion membrane remodeling venom calcium independent releases AA arachidonic acids physiologic stimuli irreversible chiral mechanism-based human recombinants deuterium deuterateds GC/MS LC/MS LC-MS GC-MS mass spectrometry MS signalling standards
Product Overview:
(R)-Bromoenol lactone-d7 ((R)-BEL-d7) contains seven deuterium atoms at the 2, 3, 4, 5, 6, 7, and 8 positions. It is intended for use as an internal standard for the quantification of (R)-BEL by GC- or LC-mass spectrometry (MS). The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components.{6940} The calcium-independent phospholipase A2 (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of iPLA2γ. Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 µM.{12978} (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM.
Size 100 µg
Shipping dry ice
Molecular Formula C16H6BrD7O2
SMILES [2H]C1=C([2H])C([2H])=C2C(C([2H])=C([2H])C([2H])=C2[C@]3([H])C(O/C(CC3)=C/Br)=O)=C1[2H].CC
Molecular Weight 324,2
Formulation A solution in methyl acetate
Purity ≥99% deuterated forms (d1-d7)
Custom Code 2932.20
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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