Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Sulforaphane

  • Zoom
    Sulforaphane
  • Sulforaphane
Cat No: 10496
Biochemicals - Small Molecule Inhibitors
Cayman
€44.00
Price is excluding VAT and does not include packaging neither shipping

Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in...

More

This product can only be bought through Cayman Chemical. Please contact us.

- +
Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 1-isothiocyanato-4-(methylsulfinyl)-butane
Correlated keywords:
  • sulforaphan Nrf2 antioxidant ARE Keap1 oxidative stress inflammations cancers apoptosis inducers inhibitors HDAC antitumors cells cycles arrest isothiocyanate cruciferous vegetables broccoli chemopreventative enzymes inhibits inhibitions Keap1-Nrf2 class I II tumors apoptosis prostates epithelial anti-tumors anti anti-oxidant oxidant anticancer antiinflammatory DL-sulforaphane
Product Overview:
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress.{17702} Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1.{16386} Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents.{20661} Sulforaphane is an isothiocyanate derived from cruciferous vegetables, including broccoli, that potently induces chemopreventative enzymes via Keap1-Nrf2 signaling and ARE-driven gene expression.{21473} At 15 μM, sulforaphane inhibits class I and II HDAC activity and suppresses tumor growth by inducing cell cycle arrest and apoptosis selectively in various cancerous prostate epithelial cells without affecting normal cells.{19710}
Size 5 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
CAS Number 4478-93-7
Molecular Formula C6H11NOS2
SMILES CS(CCCCN=C=S)=O
Molecular Weight 177,3
Formulation A solution in ethanol
Purity ≥98%
Custom Code 2930.90
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Sulforaphane There are 10 products.

Search