Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Rhein

  • Zoom
    Rhein
  • Rhein
Cat No: 17345
Biochemicals - Kinase Inhibitors
Cayman
€65.00
Price is excluding VAT and does not include packaging neither shipping

Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein (Item No. 11710). At 10 µM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the ma...

More

This product can only be bought through Cayman Chemical. Please contact us.

- +
Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
Correlated keywords:
  • Inflammation cancer angiogenesis fibrosis pancreatitis diabetes anti-inflammatory anti-cancer biochemical natural product inhibitor anthraquinone Rhubarb yellow Rheinic Monorhein Chrysazin-3-carboxylic Cassic NSC38629 derivative diacerein inhibit IL-1β IL1β signaling NF-κB matrix metalloprotease MMP-1 MMP1 MMP-13 MMP13 IKKβ iNOS IL-6 IL6 macrophage LPS-stimulated TNF-α HMBG1 pancreatic fibrosis chronic hyperglycemia β-cell apoptosis breast normoxic hypoxic
Product Overview:
Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein (Item No. 11710). At 10 µM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.{25637} It inhibits IKKβ (IC50 = 11.8 µM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression.{28412} Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis.{28415,28141} It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.{28413}
Size 100 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 478-43-3
Molecular Formula C15H8O6
SMILES O=C1C2=C(C=C(C(O)=O)C=C2O)C(C3=CC=CC(O)=C31)=O
Molecular Weight 284,2
Formulation A crystalline solid
Purity ≥95%
Custom Code 2916.39
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Rhein There are 10 products.

Search