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Programmed Cell Death Protein 4 (C-Term) Polyclonal Antibody

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    Programmed Cell Death Protein 4 (C-<wbr/>Term) Polyclonal Antibody
  • Programmed Cell Death Protein 4 (C-<wbr/>Term) Polyclonal Antibody
Cat No: 10250
Antibodies - Polyclonal Antibodies
Cayman
€342.00
Price is excluding VAT and does not include packaging neither shipping

Programmed cell death protein 4 (PDCD4) levels are elevated during apoptosis and absent in many cancer samples.{16340,16167} Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower m...

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: 500 µl

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Correlated keywords:
  • western blots WB KLH genes tumors antibodies antiserum antisera PDCD4 PCDC-4 PDCDP4 PDCDP-4 blotting immunoblotting
Product Overview:
Programmed cell death protein 4 (PDCD4) levels are elevated during apoptosis and absent in many cancer samples.{16340,16167} Loss of PDCD4 expression is an important event in cancer cell progression whereas the restoration of PDCD4 protein can lower metalloproteinase activity and possible metastasis.{16167,16166} The known isoforms of PDCD4 differ only at the N-terminial with isoform 1 comprised of 468 amino acids and isoform 2 comprised of 458 amino acids. Each isoform contains two MA-3 domains essential for binding of PDCD4 binding to eIF4A, thereby suppressing cell cycle regulation and growth factor production.{16167,16166,16345} This antibody is capable of detecting both PDCD4 isoforms. Additional protein modifications are possible and can explain the range of masses detected by immunoblotting (52-64 kDa).{16340} The molecular mechanisms of PDCD4 influence on tumor suppression are becoming known but warrant further research.{16167,16166,16168}
Size 500 µl
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
Host Rabbit
Antigen Synthetic peptide from the C-terminal region of human protein
Application(s)

WB

Formulation 500 µl of peptide-affinity purified antibody
Custom Code 3822.00
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : Programmed Cell Death Protein 4 (C-<wbr/>Term) Polyclonal Antibody There are 3 products.

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