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(+)-D-threo-PDMP (hydrochloride)

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    (+)-D-<em>threo</em>-<wbr/>PDMP (hydro<wbr/>chloride)
  • (+)-D-<em>threo</em>-<wbr/>PDMP (hydro<wbr/>chloride)
Cat No: 10178
Biochemicals - Small Molecule Inhibitors
Price is excluding VAT and does not include packaging neither shipping

(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase.{11391,11341} It inhibits glucosylceramide synthase by 50% when used at ...

: 10 mg

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Territorial Availability: Available through Bertin Technologies only in Europe
  • N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride
Correlated keywords:
  • 109836-82-0 (+)PDMP B-16 ​DPDMP HCl
Product Overview:
(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Item No. 62595).{11392} (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase.{11391,11341} It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 μM in an enzyme assay.{11341} (+)-D-threo-PDMP is the active component of racemic DL-threo-PDMP (Item No. 10005276). In vitro, (+)-D-threo-PDMP inhibits the synthesis of glucosylceramide synthase and lactosylceramide in B16 melanoma cells when used at a concentration of 25 µM and inhibits cell binding to laminin and collagen when used at concentrations of 10 and 25 µM.{36024} It also inhibits β-1,4-galactosyltransferase 6 (B4GALT6) and prevents lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} (+)-D-threo-PDMP inhibits ganglioside biosynthesis, reduces long-term potentiation (LTP) in mouse hippocampal CA1 neurons, and impairs learning in the four-pellet taking test in mice.{36881} [Matreya, LLC. Catalog No. 1756]
Size 10 mg
Shipping dry ice
CAS Number 139889-62-6
Molecular Formula C23H38N2O3 • HCl
Molecular Weight 427
Formulation A solid
Purity ≥98%
Custom Code 2942.00
UNSPSC code 12352100

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