DL-threo-PDMP (hydrochloride)

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DL-threo-PDMP (hydrochloride)

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Cat No: 10005276

Biochemicals - Small Molecule Inhibitors

DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo-(1R,2R)-PDMP and L-threo-(1S,2S)-PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide, monohydrochloride

Correlated keywords:

analog analogue inhibit inhibitor cytotoxicity glucosylceramide synthase chirality stereoisomer sphingosine (±)PDMP ceramide cultured cell treatment cellular cycle arrest alkaline cereamidase isomer ?-1,4-galactosyltransferase 6 lactosylceramide neuroinflammation promoter mice mouse chronic autoimmune encephalomyelitis multiple sclerosis MS

Product Overview:
DL-threo PDMP is a mixture of ceramide analogs that contains two of the four possible stereoisomers of PDMP (Item No. 62595): D-threo-(1R,2R)-PDMP and L-threo-(1S,2S)-PDMP.{11392} DL-threo-PDMP inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates when used at concentrations of 5 and 10 µM.{11341} It reduces the synthesis of glucosylceramide, increases cellular ceramide, and induces cell cycle arrest in vitro.{11342} The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo-(1R,2R) enantiomer.{11393} The D-threo-PDMP enantiomer is also responsible for inhibition of β-1,4-galactosyltransferase 6 and prevention of lactosylceramide synthesis, which is a promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.{27728} DL-threo-PDMP increases amyloid-β (1-42) (Aβ42) and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity in HEK293 cells expressing the γ-secretase substrate SC100.{36880} [Matreya, LLC. Catalog No. 1719]

Size	10 mg
Shipping	dry ice
CAS Number	80938-69-8
Molecular Formula	C₂₃H₃₈N₂O₃ • HCl
SMILES	CCCCCCCCCC(N([H])[C@H]([C@@H](O)C1=CC=CC=C1)CN2CCOCC2)=O.Cl
Molecular Weight	427
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2942.00
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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