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1-Palmitoyl-2-hydroxy-sn-glycero-3-PC

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    1-Palmitoyl-<wbr/>2-hydroxy-<em>sn</em>-<wbr/>glycero-3-PC
  • 1-Palmitoyl-<wbr/>2-hydroxy-<em>sn</em>-<wbr/>glycero-3-PC
Cat No: 10172
Biochemicals - Lipids
Cayman

1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.{11139} It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (7R)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphapentacosan-1-aminium, inner salt, 4-oxide
Correlated keywords:
  • Lipopolysaccharide ERK-1 ERK2 PLA-2 IL6 IL1? IL12 TNF? CD-163 206 36 IL10 TGF?1 Fox-p3 Foxp-3 Hexadecanoyllysolecithin lysophosphatidylcholine Palmitoyllecithin Palmitoyllysophosphatidylcholine Palmitoyllysolecithin Lysopalmitoylphosphatidylcholine Palmitoyllysophosphatidylcholine MPPC lysolecithin
Product Overview:
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine.{11139} It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 µM.{42919} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 µM.{42920} It increases TGF-β1 production and enhances Foxp3 protein levels in Treg cells in isolated human peripheral blood when used at a concentration of 10 µM.{42921} 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.{11693}
Size 25 mg
Shipping dry ice
CAS Number 17364-16-8
Molecular Formula C24H50NO7P
SMILES CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(=O)(O)OCC[N](C)(C)C
Molecular Weight 495,6
Formulation A crystalline solid
Purity ≥98%
Custom Code 2915.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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