BAY 41-2272

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BAY 41-2272

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Cat No: 10057

Biochemicals - Small Molecule Activators

Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain.{24381} The binding of NO to H-NOX induces sGC to gene...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine

Correlated keywords:

receptors agonists hypertension vascular diseases nitric oxides soluble guanylate cyclases sGC NO BAY41-2272 BAY-41-2272 BAYs 41-2272 412272 BAY-412272 BAY412272 pyrazolopyridine activates activators cGMPs platelets aggregation in vivo arterial bloods pressures hypertensive YC1 YC-1 YCs 1 one compounds stimulating activity levels induces relaxations phenylephrine-preconstrcicted phenylephrine preconstricted rabbits aortas rings reduces proliferation smooth muscles mean rats inhibit inhibitors inhibition phosphodiesterases

Product Overview:
Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain.{24381} The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM.{9717} Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.{9717,24380} BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats.{9717} Unlike another sGC activator, YC-1 (Item No. 81560), BAY 41-2772 does not inhibit phosphodiesterases.{17529}

Size	5 mg
Shipping	dry ice
CAS Number	256376-24-6
Molecular Formula	C₂₀H₁₇FN₆
SMILES	FC(C=CC=C1)=C1CN2N=C(C3=NC=C(C4CC4)C(N)=N3)C5=CC=CN=C52
Molecular Weight	360,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.