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BAY 41-2272

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    BAY 41-<wbr/>2272
  • BAY 41-<wbr/>2272
Cat No: 10057
Biochemicals - Small Molecule Activators

Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain.{24381} The binding of NO to H-NOX induces sGC to gene...


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Territorial Availability: Available through Bertin Technologies only in France
  • 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
Correlated keywords:
  • receptors agonists hypertension vascular diseases nitric oxides soluble guanylate cyclases sGC NO BAY41-2272 BAY-41-2272 BAYs 41-2272 412272 BAY-412272 BAY412272 pyrazolopyridine activates activators cGMPs platelets aggregation in vivo arterial bloods pressures hypertensive YC1 YC-1 YCs 1 one compounds stimulating activity levels induces relaxations phenylephrine-preconstrcicted phenylephrine preconstricted rabbits aortas rings reduces proliferation smooth muscles mean rats inhibit inhibitors inhibition phosphodiesterases
Product Overview:
Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain.{24381} The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM.{9717} Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.{9717,24380} BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats.{9717} Unlike another sGC activator, YC-1 (Item No. 81560), BAY 41-2772 does not inhibit phosphodiesterases.{17529}
Size 5 mg
Shipping dry ice
CAS Number 256376-24-6
Molecular Formula C20H17FN6
Molecular Weight 360,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2903.99
UNSPSC code 12352100

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