Clioquinol

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Clioquinol

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Cat No: 10021

Biochemicals - Anti-Infection

Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectivel...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-chloro-7-iodo-8-quinolinol

Correlated keywords:

22112-03-4 736176-41-3 anti-microbial Aspergillus Alchloquin Amebil Amoenol Bactol Barquinol Budoform Chinoform Chloroiodoquin Chloroiodoquine Chlorojodochin Cifoform Cliquinol Cort-Quin Dioquinol Dizenterol Eczecidin Emaform Entero-Vioform Enteroquinol Enteroseptol Enterozol Entrokin Hi-Eneterol Hi-Enterol Iodenterol Iodochlorhydroxyquinol Iodochloroquine Iodochloroxine Iodochloroxyquinoline Iodoenterol Iodoxyquinoline Lekosept Nioform Quin-O-Creme Quinambicide Quinidochlor Quiniodochlor Quinoform Rheaform Boluses Rometin Vioform Vioformio Fe Zn Cu NSC3531 NSC74938

Product Overview:
Clioquinol is a metal-chelating antimicrobial agent with neuroprotective properties.{46036,46037,46038} It inhibits the growth of A. fumigatus with MIC values of 1, >32, 8, and 16 µg/ml in media containing no metal, iron, zinc, and copper, respectively.{46036} Clioquinol (37 mg/kg) decreases neuronal loss in the substantia nigra pars compacta (SNc) and increases time spent in the novel arm of a Y-maze in the α-synuclein hA53T transgenic mouse model of Parkinson's disease.{46037} It reduces brain atrophy and iron content, increases nigral tyrosine hydroxylase phosphorylation, and rescues behavioral impairments in the rotarod and Y-maze tests in tau knockout mice.{46038}

Size	5 mg
Shipping	dry ice
CAS Number	130-26-7
Molecular Formula	C₉H₅ClINO
SMILES	OC1=C2C(C=CC=N2)=C(Cl)C=C1I
Molecular Weight	305,5
Formulation	A solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352300

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.