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1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)

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    1-Arachi<wbr/>donoyl Lysophos<wbr/>phatidic Acid (ammonium salt)
  • 1-Arachi<wbr/>donoyl Lysophos<wbr/>phatidic Acid (ammonium salt)
Cat No: 10019
Biochemicals - Lipids
Cayman
€46.00
Price is excluding VAT and does not include packaging neither shipping

1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl ...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • (5Z,8Z,11Z,14Z)-eicosatetraenoic acid, (2R)-hydroxy-3-(phosphonooxy)propyl ester, monoammonium salt
Correlated keywords:
  • 65446-08-4 PA(20:4(5Z,8Z,11Z,14Z)/0:0) sn1 LPA-2 EDG-4 TNFα IL6 HT29 20:4LPA 1AG lipopolysaccharide PA 5Z 8Z 11Z 14Z 0:0 20:4 LPA 3PA Lyso-phosphatidic
Product Overview:
1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol (1-AG; Item No. 62150).{10322} 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM.{43503} It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS.{43504} It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.{43505}
Size 500 µg
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
CAS Number 799268-65-8
Molecular Formula C23H38O7P • NH4
SMILES O[C@@H](COP([O-])(O)=O)COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O.[NH4+]
Molecular Weight 475,6
Formulation A solution in H2O:MeOH:NH4OH (41:25:1)
Purity ≥95%
Custom Code 2916.19
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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