Cyclopentenone Prostaglandin HPL

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Cyclopentenone Prostaglandin HPLC Mixture

Cat No: 10000

Biochemicals - Lipids

This mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors. Contents: 100 µg of each compound Prostaglandin A2 (Item No. 10210) Prostaglandin B2 (Item No. 11210) Prostaglandin D2 (Item No. 12010) Prostagl...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

PGA2 PGB2 PGD2 PGE2 15-deoxy-.DELTA.12,14-PGJ2 prostaglandins mixtures chromatography 15-deoxy-delta12,14-PGJ2 cyclopentenones UV-absorbing 15-deoxy-d12,14-PGJ2

Product Overview:
This mixture contains all of the major UV-absorbing cyclopentenone prostaglandins and their precursors. Contents: 100 µg of each compound Prostaglandin A2 (Item No. 10210) Prostaglandin B2 (Item No. 11210) Prostaglandin D2 (Item No. 12010) Prostaglandin E2 (Item No. 14010) Prostaglandin J2 (Item No. 18500) 15-deoxy-Δ12,14-Prostaglandin J2 (Item No. 18570) PGE2 and PGD2 are both chemically unstable. In the absence of any enzymatic influence, both are undergo dehydration to form the highly UV active cyclopentenone compounds PGA2 and PGJ2, respectively.{1593,1742} These compounds absorb in the ultraviolet with maxima at 216 - 220 lambda. The cyclopentenone prostaglandins have been noted to have antimitotic, antiviral and antitumor activity in a number of systems.{335,870} PGA2 and PGJ2, can also undergo further elimination and double bond rearrangements to give PGB2 and 15-deoxy-Δ12,14 PGJ2, respectively. 15-deoxy-Δ12,14 PGJ2 is a relatively potent ligand for the PPARγ nuclear receptor. PGB2 does not appear to have significant intrinsic biological activity; however, it is frequently used as a reliable internal standard for analysis of eicosanoids by HPLC.

Size	1 ea
Shipping	dry ice
Formulation	A solution in methyl acetate
Purity	≥98% for each compound
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.