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DS16570511

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    DS16570511
  • DS16570511
Cat No: 24160
Biochemicals - Ion Channel Modulation
Cayman

DS16570511 is an inhibitor of the mitochondrial calcium uniporter.{43404} It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). DS16570511 inhibits fetal bovine se...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-[3-[[[3-(2,6-dichlorophenyl)-5-methyl-4-isoxazolyl]methyl]amino]benzoyl]-1H-indole-1-butanoic acid
Correlated keywords:
  • DS-16570511 HEK-293A HEK293-A HEK-293 MICU-1
Product Overview:
DS16570511 is an inhibitor of the mitochondrial calcium uniporter.{43404} It inhibits calcium uptake by mitochondria isolated from HEK293A cells, rat heart, and pig heart (IC50s = 0.86, 25, and 15 μM, respectively). DS16570511 inhibits fetal bovine serum-induced mitochondrial calcium influx as well as MCU- and MICU1-dependent increases in calcium influx in HEK293A cells (IC50 = 7 μM) but has no effect on mitochondrial membrane potential. Ex vivo, DS16570511 inhibits mitochondrial calcium overload induced by high calcium concentrations in isolated rat hearts. It also reversibly increases cardiac contractility without affecting heart rate.
Size 1 mg
Shipping dry ice
CAS Number 2446154-84-1
Molecular Formula C30H25Cl2N3O4
SMILES O=C(C1=CN(CCCC(O)=O)C2=C1C=CC=C2)C3=CC(NCC4=C(C)ON=C4C5=C(Cl)C=CC=C5Cl)=CC=C3
Molecular Weight 562,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2903.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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