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20-HEPE

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    20-HEPE
  • 20-HEPE
Cat No: 19322
Biochemicals - Ion Channel Modulation
Cayman

20-HEPE is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110
21908
90110.1) that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B.{37628} It activates peroxisome proliferator-activated recepto...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 20-hydroxy-5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid
Correlated keywords:
  • 20HEPE CYP450 CYP-4F3B PPAR-? COS7 mTRPV-1 anti-nociceptive P-450
Product Overview:
20-HEPE is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110
21908
90110.1) that is formed via ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B.{37628} It activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter when used at a concentration of 10 μM. 20-HEPE also activates murine transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks antinociceptive activity in rats.{37629}
Size 25 µg
Shipping dry ice
CAS Number 116477-57-7
Molecular Formula C20H30O3
SMILES OCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Molecular Weight 318,5
Formulation A solution in methyl acetate
Purity ≥95%
Custom Code 2916.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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