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Carbidopa (hydrate)

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    Carbidopa (hydrate)
  • Carbidopa (hydrate)
Cat No: 23783
Biochemicals - Small Molecule Inhibitors
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

Carbidopa is a peripherally-restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Item No. 13248) to dopamine.{41269} Carbidopa (100 mg/kg) pretreatment in dog increases the plasma concentration of L-DOPA by 186% and prolong...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (αS)-α-hydrazinyl-3,4-dihydroxy-α-methyl-benzenepropanoic acid, monohydrate
Correlated keywords:
  • 27925-91-3 31823-41-3 28860-95-9 HMD Methyldopahydrazine Lodosin Lodosyn MK486 MK-486 Aminomethyldopa levodopa N-aminomethyl DOPA Carbi-dopa
Product Overview:
Carbidopa is a peripherally-restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Item No. 13248) to dopamine.{41269} Carbidopa (100 mg/kg) pretreatment in dog increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by 66%.{41270} Carbidopa also binds to and potentiates the activity of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons.{41271} It inhibits the proliferation of pancreatic cancer cells in vitro and tumor growth in vivo. Formulations containing carbidopa are used in combination with L-DOPA in the treatment of Parkinson’s disease to increase the amount of dopamine in the brain and reduce peripheral side effects associated with L-DOPA administration.
Size 25 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 38821-49-7
Molecular Formula C10H14N2O4 • H2O
SMILES OC1=C(O)C=CC(C[C@](C)(NN)C(O)=O)=C1.O
Molecular Weight 244,2
Formulation A solid
Purity ≥98%
Custom Code 2907.29
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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