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Nicotinamide riboside

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    Nicotinamide riboside
  • Nicotinamide riboside
Cat No: 23132
Biochemicals - Small Molecule Activators

Nicotinamide riboside is a riboside form of nicotinamide (Item No. 11127) that is found in trace amounts in yeast-containing and milk-derived products.{38460} It is a precursor of NAD+ (Item No. 16077) and a source of vitamin B3 (niacin). Nicotinamide...


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Territorial Availability: Available through Bertin Technologies only in France
  • 3-(aminocarbonyl)-1-?-D-ribofuranosyl-pyridinium
Correlated keywords:
  • 23111-00-4 19131-72-7 20299-13-2 954368-04-8 ribose ribonucleoside Ribosyl HEK-293 Hepa-1.6 FOX-O1 SOD-2 SIRT-1 2 3 Ribosylnicotinamide adenine dinucleotide C2C-12 forkhead box class O1 Superoxide dismutase
Product Overview:
Nicotinamide riboside is a riboside form of nicotinamide (Item No. 11127) that is found in trace amounts in yeast-containing and milk-derived products.{38460} It is a precursor of NAD+ (Item No. 16077) and a source of vitamin B3 (niacin). Nicotinamide riboside increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1,000 μM.{38461} It also decreases acetylation of FOXO1 and SOD2, which are substrates of sirtuin 1 (SIRT1) and SIRT3, respectively, but not the SIRT2 substrate tubulin, indicating nicotinamide riboside selectively enhances SIRT1 and 3 deacetylase activity. Nicotinamide riboside (400 mg/kg per day) increases NAD+ levels in liver and skeletal muscle and prevents body weight gain in mice fed a high-fat diet. It also increases NAD+ in the cerebral cortex and reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.{38462}
Size 1 mg
Shipping dry ice
CAS Number 1341-23-7
Molecular Formula C11H15N2O5
SMILES NC(C1=C[N+]([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=CC=C1)=O
Molecular Weight 255,3
Formulation A low melting semi-solid
Purity ≥95% Contains ~80% cyclodextrin as stabilizer
Custom Code 2933.39
UNSPSC code 12352100

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