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  • Escitalopram
Cat No: 22405
Biochemicals - Transporter & Exchanger Modulators

Escitalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and the (S) isomer of citalopram (Item No. 14572) and (R)-citalopram.{38120} It selectively binds to SERT (Ki = 0.89 nM) over the norepinephrine and dopamine transporters (Kis = >1...


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Territorial Availability: Available through Bertin Technologies only in France
  • (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile
Correlated keywords:
  • 219861-08-2 seroplex 5HT ppVSV SARSCoV2 COVID-19 COVID19
Product Overview:
Escitalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and the (S) isomer of citalopram (Item No. 14572) and (R)-citalopram.{38120} It selectively binds to SERT (Ki = 0.89 nM) over the norepinephrine and dopamine transporters (Kis = >10,000 and 8,150 nM, respectively) and inhibits 5-HT reuptake in rat brain synaptosomes (IC50 = 2.1 nM).{64079,38121} Escitalopram reduces immobility in the forced swim test in mice (ED50 = 12 mg/kg), indicating anti-depressant-like activity, and increases exploratory behavior in the black-and-white box test in mice with a minimal effective dose (MED) of 0.49 mg/kg, indicating anxiolytic-like activity.{64080} Escitalopram (20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681).{54655} Formulations containing escitalopram have been used in the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
Size 5 mg
Shipping dry ice
CAS Number 128196-01-0
Molecular Formula C20H21FN2O
Molecular Weight 324,4
Formulation A solution in ethanol
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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