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Fluvoxamine (maleate)

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    Fluvoxamine (maleate)
  • Fluvoxamine (maleate)
Cat No: 15617
Biochemicals - Ion Channel Modulation
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiati...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime, 2Z-butenedioate
Correlated keywords:
  • 54739-​20-​7 54739-18-3 SSRI SRI selective serotonin reuptakes inhibitors inhibits inhibitions sigma agonists OCD obsessive-compulsive obsessive compulsive disorders anti-depressants anti depressants 5HTs HTs 5 antidepressants anxiolytic 5-HT HERG channels IKr delayed rectifier calcium currents cardiac diseases σ1 sigma-1 receptors cardioprotective brain neurosciences selective avoskin avoxin DUs 23000 DU23000 DU-23000 depromel dumirox faverin 50 faverine maveral MKs 264 MK-264 MK264 NSCs 309469 NSC-309469 NSC309469 5-hydroxytryptophan central nervous system CNS .sigma.1 sigma1 σ .sigma. sigma 1 one
Product Overview:
Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}
Size 10 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 61718-82-9
Molecular Formula C15H21F3N2O2 • C4H4O4
SMILES COCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O
Molecular Weight 434,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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