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Fluvoxamine (maleate)

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    Fluvoxamine (maleate)
  • Fluvoxamine (maleate)
Cat No: 15617
Biochemicals - Ion Channel Modulation
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Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiati...


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Territorial Availability: Available through Bertin Technologies only in Europe
  • (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime, 2Z-butenedioate
Correlated keywords:
  • 54739-​20-​7 54739-18-3 SSRI SRI selective serotonin reuptakes inhibitors inhibits inhibitions sigma agonists OCD obsessive-compulsive obsessive compulsive disorders anti-depressants anti depressants 5HTs HTs 5 antidepressants anxiolytic 5-HT HERG channels IKr delayed rectifier calcium currents cardiac diseases σ1 sigma-1 receptors cardioprotective brain neurosciences selective avoskin avoxin DUs 23000 DU23000 DU-23000 depromel dumirox faverin 50 faverine maveral MKs 264 MK-264 MK264 NSCs 309469 NSC-309469 NSC309469 5-hydroxytryptophan central nervous system CNS .sigma.1 sigma1 σ .sigma. sigma 1 one
Product Overview:
Fluvoxamine selectively inhibits the reuptake of serotonin (Ki = 6.2 nM in rat hypothalamus) with comparatively little effect on noradrenaline reuptake (Ki = 1,100 nM), resulting in decreased serotonin turnover in the brain.{25681,25680} By potentiating the pharmacological effects of serotonin and its precursor, 5-hydroxy tryptophan, in the central nervous system, fluvoxamine is known to exhibit antidepressant effects.{25680} At higher concentrations, fluvoxamine can block the activity of HERG channels (IC50 = 3.8 µM), which carry the delayed rectifier potassium current that is important for repolarization of ventricular action potentials over the course of normal cardiac functioning.{25679} It also has been reported to exhibit cardioprotective effects by stimulating the σ1 receptor.{25678}
Size 10 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 61718-82-9
Molecular Formula C15H21F3N2O2 • C4H4O4
Molecular Weight 434,4
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Cross selling for this product : Fluvoxamine (maleate) There are 10 products.