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(±)8(9)-DiHETE

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    (±)8(9)-<wbr/>DiHETE
  • (±)8(9)-<wbr/>DiHETE
Cat No: 10473
Biochemicals - Lipids
Cayman

(±)8(9)-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid (EPA; Item No. 90110).{13149} It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetrae...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 8,9-dihydroxy-5Z,11Z,14Z,17Z-eicosatetraenoic acid
Correlated keywords:
  • EPA metabolite eicosapentaenoic microsome 8,9-epoxyeicosatetraenoic CYP450 vicinal diol ?-3 ?3 20:5
Product Overview:
(±)8(9)-DiHETE is a major metabolite of the 20:5 ω-3 fatty acid eicosapentaenoic acid (EPA; Item No. 90110).{13149} It is produced in rat liver microsomes, but not renal microsomes, by the generation of the unstable intermediate 8,9-epoxy eicosatetraenoic acid from EPA by cytochrome P450 monooxygenases.{13149} Dietary EPA supplementation in humans results in substantial urinary excretion of vicinal diols, including 8,9, 11,12, and 14,15 forms.{996}
Size 25 µg
Shipping dry ice
CAS Number 867350-87-6
Molecular Formula C20H32O4
SMILES CC/C=C\C/C=C\C/C=C\C[C@@H](O)[C@H](O)C/C=C\CCCC(O)=O
Molecular Weight 336,5
Formulation A solution in ethanol
Purity ≥98%
Custom Code 2916.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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