Ethacrynic Acid

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Ethacrynic Acid

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Cat No: 19536

Biochemicals - Transporter & Exchanger Modulators

Ethacrynic acid is a loop diuretic with anticancer activity.{53194},{33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]-acetic acid

Correlated keywords:

105656-03-9 anti cancer NaK NakK2Cl 2 Cl K2Cl erythro P11 P 11 GSTP11 GSTP GSTA33 GSTA 3 ?catenin cyto toxic MCF7 MDAMB MDAMB231 MB231 4 T1 T MK595 NSC85791 NSC624008

Product Overview:
Ethacrynic acid is a loop diuretic with anticancer activity.{53194},{33064,33063} It inhibits the Na-K-2Cl (NKCC) cotransporter in duck erythrocytes (IC50 = 0.18 mM) and ATP-dependent chloride uptake in rat renal plasma membrane vesicles when used at a concentration of 0.3 mM.{53194},{33062} Ethacrynic acid also inhibits glutathione S-transferase P1-1 (GSTP1-1) and GSTA3-3 (IC50s = 4.9 and ~0.4 μM, respectively), and inhibits Wnt/β-catenin signaling in a cell-based reporter assay.{41510,33064} It is cytotoxic to primary chronic lymphocytic leukemia cells (IC50 = 8.56 μM), as well as MCF-7, MDA-MB-231, and 4T1 cancer cells (IC50s = 45.53, 39.64, and 25.23 μM, respectively).{33064,33063} Ethacrynic acid (250 μg per day) increases tumor growth reduction induced by the EGFR family inhibitors afatinib (Item Nos. 11492
21567) or neratinib (Item No. 18404) in a 4T1 murine breast cancer model.{33063} Formulations containing ethacrynic acid have been used in the treatment of edema.

Size	1 g
Shipping	dry ice
CAS Number	58-54-8
Molecular Formula	C₁₃H₁₂Cl₂O₄
SMILES	O=C(C(CC)=C)C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1
Molecular Weight	303,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.