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MreB Perturbing Compound A22

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    MreB Perturbing Compound A22
  • MreB Perturbing Compound A22
Cat No: 15870
Biochemicals - Anti-Infection
Cayman

MreB is an actin-like protein expressed in bacteria.{25735} It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity.{25734} MreB perturbing compound A22 is a benzylisothiourea compound tha...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • carbamimidothioic acid,(3,4-dichlorophenyl)methyl ester, monohydrochloride
Correlated keywords:
  • 22297-13-8 inhibitors antibiotics cytoskeletal research inhibits inhibitions reversible functions actin-like actin like proteins bacteria benzylisothiourea ATP binding binders binds E. coli cells shapes nucleoid morphology alterations alters alterating rods formations chromosomes partitioning segregation S-(3,4-Dichlorobenzyl)thiouronium chloride HCL hydrochloride monohydrochloride 2-(3,4-Dichloro-benzyl)-isothiourea
Product Overview:
MreB is an actin-like protein expressed in bacteria.{25735} It determines the rod shape of cells and has critical roles in cell division, chromosome segregation, and cell polarity.{25734} MreB perturbing compound A22 is a benzylisothiourea compound that interacts with the ATP binding site of MreB rapidly and reversibly.{25730} It blocks normal rod shape formation and inhibits chromosome partitioning in E. coli, inhibiting growth (MIC = 3.1 µg/ml).{25731} It interferes with chromosome segregation in C. crescentus by preventing MreB binding to chromosomes.{25730} In V. cholerae, A22 prevents the development of normal cell shape and alters nucleoid morphology.{25733}
Size 10 mg
Shipping dry ice
CAS Number 22816-60-0
Molecular Formula C8H8Cl2N2S • HCl
SMILES ClC1=CC(CSC(N)=N)=CC=C1Cl.Cl
Molecular Weight 271,6
Formulation A crystalline solid
Purity ≥95%
Custom Code 2930.90
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

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