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(±)14(15)-EpETE

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    (±)14(15)-EpETE
  • (±)14(15)-EpETE
Cat No: 10173
Biochemicals - Lipids
Cayman

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilator...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (±)14,15-epoxy-5Z,8Z,11Z,17Z-eicosatetraenoic acid
Correlated keywords:
  • epoxides epoxygenases cytochrome P450 (±)14,15-EpETEs (+/-)14,15-EpETEs fatty acids (+/-)14(15)EpETrEs 14(15)EETs eicosatrienoic 14,15-EEQ 14,15EEQ
Product Overview:
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.{6485,7204} Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE (Item No. 50651) which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined.
Size 25 µg
Shipping dry ice
CAS Number 131339-24-7
Molecular Formula C20H30O3
SMILES CC/C=C\C[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\CCCC(O)=O
Molecular Weight 318,5
Formulation A solution in ethanol
Purity ≥90%
Custom Code 2910.90
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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