TTNPB

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TTNPB

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Cat No: 16144

Biochemicals - Receptor Pharmacology

TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).{27011,23075} It does not act on retinoid X receptors and weakly ag...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(1E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]-benzoic acid

Correlated keywords:

111035-?66-?6 101204-37-9 110917-84-5 receptors agonists signals transductions stems cells research nuclear retinoic acids RARs actions epidermal proliferation embryogenesis differentiation potent selective AGNs 191183 AGN191183 AGN-191183 arotinoid Ros 13-7410 137410 Ro-13-7410 Ro-137410 Ro13-7410 Ro137410 Ro-13 7410 Ro13 13 biochemicals RAR? RAR? RAR? RAR-? RAR-? RAR-? ? ? ?

Product Overview:
TTNPB is an analog of retinoic acid (Item No. 11017) that potently and selectively activates retinoic acid receptors (EC50s = 21, 4, and 2.4 nM for RARα, RARβ, and RARγ, respectively).{27011,23075} It does not act on retinoid X receptors and weakly agonizes farnesoid X receptor (EC50 > 1 µM).{23075,12563} TTNPB is used to study RAR action in diverse processes, including epidermal cell proliferation, embryogenesis, and stem cell differentiation.{27013,27012,25645,27014}

Size	1 mg
Shipping	dry ice
CAS Number	71441-28-6
Molecular Formula	C₂₄H₂₈O₂
SMILES	CC1(C)C2=C(C=CC(/C(C)=C/C3=CC=C(C(O)=O)C=C3)=C2)C(C)(C)CC1
Molecular Weight	348,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2916.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.