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Interleukin-1α (human) ELISA Kit

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    Interleukin-<wbr/>1α (human) ELISA Kit
  • Interleukin-<wbr/>1α (human) ELISA Kit
Cat No: 583301
Assay Kits - Elisa
Cayman
€479.00
Price is excluding VAT and does not include packaging neither shipping

Interleukin-1 (IL-1) is a name for a family of proteins which include IL-α, IL-1β, ILra (interleukin receptor antagonist), and IL-18. IL-1α is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the acti...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
Correlated keywords:
  • enzyme-linked interleukins measures kits eias enzymes immunometrics immunosorbents immunoassays ELISAs IL1α IL-1α IL1.alpha. IL1alpha IL-1.alpha. IL-1alpha interleukin-1alpha interleukin-1.alpha. cytokines assays pro-cytokines enzymatically cleaves cleavages calpain cells types macrophages monocytes astrocytes keratinocytes adipocytes T-cells T eosinophils cell-surfaces surfaces receptors R1 R2 R-1 R-2 RI RII R-I R-II immunity inflammatory inflammations responses mediates mediating mediations host responses infections injury injuries diseases states bowels IBDs shocks atherosclerosis allergy allergies cancers sandwich
Product Overview:
Interleukin-1 (IL-1) is a name for a family of proteins which include IL-α, IL-1β, ILra (interleukin receptor antagonist), and IL-18. IL-1α is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide.{10662,10661,10667} IL-1α is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils.{866} Although IL-1α and IL-1β exhibit only 26% amino acid identity,{10662} they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses.{10660,10775,10668} Normal production of IL-1 is critical for mediating host responses to infection and injury.{7221,11054} Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergy, and some types of cancer.{7221,11054} Cayman’s IL-1α (human) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits IL-1α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml.
Size 96 wells
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
Custom Code 3822.00
UNSPSC code 41116104

Dinarello, C.A. Interleukin-1 and its biologically related cytokines. Adv Immunol 44 153-205 (1989).

Kobayashi, Y., Yamamoto, K., Saido, T., et al. Identification of calcium-activated neutral protease as a processing enzyme of human interleuki

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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