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Pranlukast

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    Pranlukast
  • Pranlukast
Cat No: 10008319
Biochemicals - Receptor Pharmacology
Cayman
€18.00
Price is excluding VAT and does not include packaging neither shipping

The cysteinyl leukotrienes (CysLTs), leukotriene C4 (LTC4; Item No. 20210) and LTD4 (Item No. 20310), are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors o...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide
Correlated keywords:
  • CysLT1 receptors cysteinyl leukotrienes asthma allergy antagonists LTC4 LTD4 hypersensitivity oral peptidyl LTRA bronchoconstriction
Product Overview:
The cysteinyl leukotrienes (CysLTs), leukotriene C4 (LTC4; Item No. 20210) and LTD4 (Item No. 20310), are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries.{45402} Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2.{7174,8519,14081} Pranlukast is a potent, selective and orally bioavailable cysteinyl CysLT1 receptor antagonist.{14104} Pranlukast is selective for the CysLT1 receptor over the CysLT2 receptor (IC50s = 1.6-4.5 nM and >1,000 nM, respectively, for the human receptors).{7174,8519,14081} Formulations containing pranlukast have been used in the treatment of asthma.
Size 10 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 103177-37-3
Molecular Formula C27H23N5O4
SMILES O=C(Nc1cccc2c(=O)cc(oc12)c1[nH]nnn1)c1ccc(OCCCCc2ccccc2)cc1
Molecular Weight 481,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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