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Illudin S

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    Illudin S
  • Illudin S
Cat No: 17451
Biochemicals - Natural Products
Cayman
€329.00
Price is excluding VAT and does not include packaging neither shipping

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential.{28238,28236} Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cyclin...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • (2'S,3'R,6'R)-2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one
Correlated keywords:
  • 1413-64-5 34426-29-4 biochemical natural product cancer DNA damage cell cycle repair illudin fungal sesquiterpene alkylating agent anticancer anti-cancer cytotoxic intracellular metabolite block G1-S G1 S phase interface myeloid T-lymphocyte leukemia CEM restant doxorubicin epipodophyllotoxin 1-β-D-arabinofuranosylcytosine NSC400979 NSC626369 lunamycin illudine
Product Overview:
Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential.{28238,28236} Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM).{28238} T-lymphocyte leukemia CEM cells that are resistant to doxorubicin (Item No. 15007), epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S.{28238} Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.{28236,28237,28239}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 1149-99-1
Molecular Formula C15H20O4
SMILES O=C1C2=C[C@](CO)(C)[C@H](O)C2=C(C)C3(CC3)[C@]1(O)C
Molecular Weight 264,3
Formulation A light yellow solid
Purity ≥98%
Custom Code 2912.49
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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