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Resolvin D1 ELISA Kit

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    Resolvin D1 ELISA Kit
  • Resolvin D1 ELISA Kit
Cat No: 500380
Assay Kits - Elisa
Cayman
€521.00
Price is excluding VAT and does not include packaging neither shipping

Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenases.{13989} The 17(R)-epimer of RvD1 can also be generated with aspirin-treatment.{11433} Both RvD1 and its 17(R) configuration reduce human p...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
Correlated keywords:
  • pain ELISAs enzymes immunoassays kits measures measurements resolvins lipids mediators eicosapentaenoic acids EPAs docosahexaenoic DHA inflammation non-inflamed state oxygenation oxygenated 15-lipoxygenase 5 lipoxygenase 15-LO 5-LO 17(R)-RvD1 17(R) epimers aspirin-treatments configurations humans polymorphonuclear leukocytes PMNL transendothelial migrations acute aspirin-triggered murine mouse mice rat model peritonitis inhibition inhibits inhibitors adjuvant-induced arthritis antihyperalgesic effects prevents attenuates post-operative pains transient receptors potentials TRP channels TRPA1 TRPV3 TRP4 anti-nociceptives phagocytes ALX GPR32 insulin sensitivity leptins (db/db) pro-inflammatory macrophages adipose tissues 10007848 17(S)-RvD1
Product Overview:
Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenases.{13989} The 17(R)-epimer of RvD1 can also be generated with aspirin-treatment.{11433} Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation. RvD1 exhibits antihyperalgesic effects in a rat model of adjuvant-induced arthritis and prevents and inhibits the TRP channels, TRPA1, TRPV3, and TRPV4,{20276,20277,20290} producing anti-nociceptive effects. Resolvins also specifically interact with human phagocytes via the ALX and GPR32 receptors and have been shown to improve insulin sensitivity in leptin receptor-deficient (db/db) mice, possibly related to the reduction of pro-inflammatory macrophages found in adipose tissues.{20279,20278} Cayman’s Resolvin D1 ELISA Kit is a competitive assay that can be used for quantification of RvD1. Due to the number and variation of potential sample types, this assay has been validated in Cayman’s ELISA Buffer (Item No. 400060) diluted to 1X (0.1 M potassium phosphate containing 0.1% BSA, 0.1% sodium chloride, 1 mM EDTA, and 0.01% sodium azide) and DMEM containing phenol red and 10% FBS. This assay has a range from 3.3-2,000 pg/ml and a sensitivity (80% B/B0) of approximately 15 pg/ml.
Size 96 strip wells
Shipping dry ice
Stability Store at -80 degrees; shelf life 365 days
Custom Code 3822.00
UNSPSC code 41116104

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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