SPM E-series LC-MS Mixture

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Cat No: 19417

Biochemicals - Lipids

This mixture contains an E-series resolvin (specialized pro-resolving mediator; SPM) and its precursors, eicosapentaenoic acid (EPA; Item No. 90110) and (±)18-HEPE (Item No. 32840). The mixture is supplied in an amber ampule in which the headspace has...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

resolvin E-series EPA eicosapentaenoic acid resolution LC-MS LC/MS 18HEPE HSV1 antiinflammatory RvE1 RvE-1 type II

Product Overview:
This mixture contains an E-series resolvin (specialized pro-resolving mediator; SPM) and its precursors, eicosapentaenoic acid (EPA; Item No. 90110) and (±)18-HEPE (Item No. 32840). The mixture is supplied in an amber ampule in which the headspace has been purged with argon to prevent lipid oxidation. This product has been designed for direct use in LC-MS applications. The solution may be serially diluted for preparation of calibrators and QC standards and/or used directly as a system suitability standard or tuning standard. After opening, we recommend that the mixture be transferred immediately to a 1 ml glass screw cap vial, to prevent solvent evaporation, and stored at -20°C. The mixture should be discarded after multiple freeze/thaw cycles.The fatty acids in this mixture represent the metabolic cascade of the E-series resolvins. Resolvin E1 (Item No. 10007848) has been postulated to be an anti-inflammatory metabolite of EPA by way of an 18-HEPE intermediate.{14504} It has been identified in mouse inflammatory exudates and in human plasma when subjects are treated with both aspirin (Item No. 70260) and supplemental EPA.{21162,11433,13210} Resolvin E1 has been shown to promote inflammatory resolution in numerous disease models, including experimental colitis, asthma, atherosclerosis, type 2 diabetes, and HSV-1-induced stromal keratitis.{13209,15876,30594,30592,30593,30595,30596}

Size	1 ea
Shipping	dry ice
Formulation	A solution in ethanol (100 ng/ml of each compound)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.