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Dimethyl fumarate

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    Dimethyl fumarate
  • Dimethyl fumarate
Cat No: 14714
Biochemicals - Ox Stress Reagents
Cayman
€24.00
Price is excluding VAT and does not include packaging neither shipping

Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways.{23442} It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate.{23442} Dimethyl fum...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 2E-butenedioic acid, 1,4-dimethyl ester
Correlated keywords:
  • Oxidative injury genes regulation inflammation angiogenesis regulates dimethylfumarate lipophilic electrophiles oxidative immunological pathways Michael addition Nrf2 Nrf-2 Nrfs 2 nuclear factors erythroid 2 related factors 2 antioxidant heme-oxygenase-1 heme oxygenase 1 one HO-1 flutathione levels pro-inflammatory pro inflammatory proinflammatory cytokines inhibits inhibitors inhibitions angiogenesis psoriasis multiple sclerosis MS fumaric acid dimethyl esters AZL-O 211089 allomaleic BG 00012 BG-00012 BG00012 boletic methyl NSCs 167432 25942 NSC-167432 NSC-25942 NSC167432 NSC25942 dimethyl fumarate glutathione monomethyl HO1 HOs 1
Product Overview:
Dimethyl fumarate is a lipophilic electrophile that has profound effects on oxidative and immunological pathways.{23442} It rapidly interacts in a Michael addition reaction with glutathione or is metabolized to monomethyl fumarate.{23442} Dimethyl fumarate at low micromolar levels activates the nuclear factor erythroid 2-related factor 2 (Nrf2), resulting in an antioxidant response featuring heme oxygenase-1 expression and increased glutathione levels.{23442} It also suppresses the expression of pro-inflammatory cytokines and inhibits angiogenesis.{23440,23439} Through these actions dimethyl fumarate alters the course of psoriasis and may reduce inflammation related to multiple sclerosis.{23440,23441}
Size 25 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 624-49-7
Molecular Formula C6H8O4
SMILES COC(/C=C/C(OC)=O)=O
Molecular Weight 144,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 2916.19
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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