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Carmustine

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    Carmustine
  • Carmustine
Cat No: 15775
Biochemicals - Dna Alkylating Agents
Cayman

Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent.{30627} It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis.{30628} Carmustine is also reporte...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N,N'-bis(2-chloroethyl)-N-nitroso-urea
Correlated keywords:
  • 1159711-?15-?5 1191292-?23-?5 Becenum Becenun BiCNU Bi-CNU Carmubris Carmustin DTI-015 FDA-0345 DTI015 FDA0345 Gliadel-Wafer Nitrumon NSC409962 SK-27702 SRI-1720 SK27702 SRI1720 A?-40 PS-1
Product Overview:
Carmustine is a nitrogen mustard β-chloro-nitrosourea compound that is used as an alkylating agent.{30627} It forms interstrand crosslinks in DNA, which prevents DNA replication and transcription leading to apoptosis.{30628} Carmustine is also reported to inhibit glutathione reductase, thioredoxin reductase, and lipoamide dehydrogenase.{5822} Carmustine has been tested in clinical trials as a cytostatic agent for Hodgkin’s and non-Hodgkin’s lymphoma, myeloma, malignant melanoma, glioblastoma, and other brain tumors.{30629}
Size 10 mg
Shipping dry ice
CAS Number 154-93-8
Molecular Formula C5H9Cl2N3O2
SMILES ClCCNC(N(N=O)CCCl)=O
Molecular Weight 214,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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