Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Chloroquine (phosphate)

  • Zoom
    Chloroquine (phosphate)
  • Chloroquine (phosphate)
Cat No: 14194
Cayman
€62.00
Price is excluding VAT and does not include packaging neither shipping

Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial and anticancer activities.{48566,48567,48568} Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 µM.{48566} It is...

More

This product can only be bought through Cayman Chemical. Please contact us.

- +
Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine, diphosphate
Correlated keywords:
  • 6384-82-3 69698-56-2 antimalarial autophagy aminoquinoline amino-quinoline anti-malarial detoxification hematin autophagosome fusion lysosome NSC 14050 NSC14050 Artrichin Bipiquin Capquin Reumachlor Ronaquine Alexoquine Arechin Avloclor Bemaphate Chingamin Chlorochin Chlorochin Chloroquin Cidoquine Delagil Gontochin Imagon Khingamin Maladrin Malaquin Nivaquine B Quingamine Quivaclor Resochin Resoquine SN 7618 SN7618 Sanoquin Tanakan Tresochin WR 1522 WR1522 aralen Plasmodium SARSCoV-2 SARSCoV2 SSC-25 CAL27 A-498 SN-12C SN-12-C SN12 RXF393 769P 4T-1
Product Overview:
Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial and anticancer activities.{48566,48567,48568} Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 µM.{48566} It is active against the chloroquine-sensitive GC03 strain of P. falciparum (IC50 = 29.2 nM) but has decreased activity against mutant pfcrt P. falciparum (IC50s = 100-150 nM).{48567} Chloroquine inhibits the growth of human SSC25 and CAL27 oral squamous cell carcinoma cells (IC50s = 29.9 and 17.3 µM, respectively), as well as A498, SN12C, RXF393, and 769-P renal cancer cells (IC50s = 16, 62, 81, and 25 µM, respectively).{48568,48570} It reduces tumor growth in a CAL27 mouse xenograft model and a 4T1 mouse allograft model when administered at a dose of 50 mg/kg.{48568,48569}
Size 25 g
Shipping dry ice
CAS Number 50-63-5
Molecular Formula C18H26ClN3 • 2H3PO4
SMILES ClC1=CC=C2C(N=CC=C2NC(C)CCCN(CC)CC)=C1.O=P(O)(O)O.O=P(O)(O)O
Molecular Weight 515,9
Formulation A crystalline solid
Purity ≥95%
Custom Code 2903.99
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Chloroquine (phosphate) There are 10 products.

Search