Histone H4 is a structural component of the nucleosome and is subject to covalent modification including acetylation and methylation, which may alter expression of genes located on DNA associated with its parent histone octamer.
The Histone H4 clone 3H...
|Antigen||synthetic peptide: MSGRG(acetyl-K)GG(acetyl-K)GLG(acetyl-K)GGA(acetyl- K)RHRKVLR-(C) corresponding to aa 1 to 24 of human histone H4. This sequence is conserved in a wide range of species.|
Recommended dilutions: 1/500-1/5000
|Formulation||Liquid Ascite, does not contain any preservative therefore avoid repeat freezing and thawing cycles|
Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, et al. (2001) UVdamaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Embo J 20: 3187-3196.
Dilworth FJ, Fromental-Ramain C, Yamamoto K, Chambon P. ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro. Mol Cell. 2000. 6(5):1049-58