SL 0101-1

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SL 0101-1

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Cat No: 11704

Biochemicals - Kinase Inhibitors

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC5...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[(3,4-di-O-acetyl-6-deoxy-?-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Correlated keywords:

kinases cycles anti-cancers anti cancers RSKs inhibitors cells proliferations p90 ribosomal S6 kinases extracellular signal-regulated ERKs MAPKs signals transductions natural product SL 01011 SL-0101-1 SL-01011 SL01011 SL0101-1 inhibits inhibitions kaempferol glycoside Forsteronia refracta F. RSK2 RSK-2 MCF-7 MCF7 MCFs breast signaling angiotensin II

Product Overview:
The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC.{22410} At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle.{22410} SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.{22411}

Size	500 µg
Shipping	dry ice
CAS Number	77307-50-7
Molecular Formula	C₂₅H₂₄O₁₂
SMILES	O=C(C(O[C@@H]1O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1O)=C(C2=CC=C(O)C=C2)O3)C4=C3C=C(O)C=C4O
Molecular Weight	516,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.29
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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