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Prion Protein Monoclonal Antibody - 2G11

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    Prion Protein Monoclonal Antibody - 2G11
  • Prion Protein Monoclonal Antibody - 2G11
Cat No: A03225
Antibodies - Monoclonal Antibodies
Bertin Bioreagent
€339.00
Price is excluding VAT and does not include packaging neither shipping

Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...

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: 200 µg

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Territorial Availability: Available worldwide directly through Bertin or your local distributor
Synonyms:
  • Prion Protein Monoclonal Antibody - 2G11
Correlated keywords:
  • proteins
  • mad
  • cow
  • diseases
  • bovine
  • spongiform
  • encephalopathy
  • scrapie
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Product Overview:
Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its human form, the New Variant of Creutzfeld-Jakob disease.
This antibody recognises the 149-161 peptide motif on the ovine sequence that is EDRYYRENMYRYP.
Size 200 µg
Shipping Dry Ice
Host Mouse
Antigen This anti-Prion Protein Monoclonal Antibody was raised against a synthetic peptide (146-182) of the ovine PrP peptide.
Clone 2G11
Isotype IgG2a
Application(s)

Reconstitute the content of the vial in 1 mL of water.

IHC for sheep PrPres without PK treatment

For immunohistochemistry, the optimal working dilution must be determined empirically (currently between 0.1 and 1 µg/mL). Mab 2G11 binds to the partially denatured or oxidized normal prion protein in vitro and as such is an indicator (by lack of signal) of preservation of the native state.

Specificity
Application Media Reconstitute the content of the vial in 1 mL of water.
Formulation lyophilized IgG with BSA
Custom Code 3822000000
UNSPSC code 12352203

Andreoletti O., Berthon P., Marc D., Sarradin P., Grosclaude J., Van Keulen L., Schelcher F., Elsen J-M., and Lantier F. (2000). Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie J.Gen Virol, 81, 3115-3126

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