Prion Protein Monoclonal Antibody - 2G11

Antibodies - Monoclonal Antibodies

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Cat No: A03225

Antibodies - Monoclonal Antibodies

Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...

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                        Territorial Availability: Available worldwide directly through Bertin or your local distributor
                    

Synonyms:

Prion Protein Monoclonal Antibody - 2G11

Correlated keywords:

proteins

diseases

bovine

spongiform

encephalopathy

scrapie

Creutzfeldt-jakob

neurodegeneration

antibodies

antisera

antiserum

neurochemistry

neuroscience

spi-bio

spibio

A03200

Product Overview:
Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its human form, the New Variant of Creutzfeld-Jakob disease.
This antibody recognises the 149-161 peptide motif on the ovine sequence that is EDRYYRENMYRYP.

Size	200 µg
Shipping	Dry Ice
Host	Mouse
Antigen	This anti-Prion Protein Monoclonal Antibody was raised against a synthetic peptide (146-182) of the ovine PrP peptide.
Clone	2G11
Isotype	IgG2a
Application(s)	Reconstitute the content of the vial in 1 mL of water. IHC for sheep PrPres without PK treatment For immunohistochemistry, the optimal working dilution must be determined empirically (currently between 0.1 and 1 µg/mL). Mab 2G11 binds to the partially denatured or oxidized normal prion protein in vitro and as such is an indicator (by lack of signal) of preservation of the native state.
Specificity	PrPres (+) Caprine, (+) Ovine, (+/-) Bovine, (+/-) Mouse, (+) Bovine Linked with 12F10, (-) Human, (-) Hamster.
Application Media	Reconstitute the content of the vial in 1 mL of water.
Formulation	lyophilized IgG with BSA
Custom Code	3822000000
UNSPSC code	12352203

Andreoletti O., Berthon P., Marc D., Sarradin P., Grosclaude J., Van Keulen L., Schelcher F., Elsen J-M., and Lantier F. (2000). Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie J.Gen Virol, 81, 3115-3126

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