Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...More
|Antigen||This anti-Prion Protein Monoclonal Antibody was raised against a synthetic peptide (146-182) of the ovine PrP peptide.|
Reconstitute the content of the vial in 1 mL of water.
IHC for sheep PrPres without PK treatment
For immunohistochemistry, the optimal working dilution must be determined empirically (currently between 0.1 and 1 µg/mL). Mab 2G11 binds to the partially denatured or oxidized normal prion protein in vitro and as such is an indicator (by lack of signal) of preservation of the native state.
|Application Media||Reconstitute the content of the vial in 1 mL of water.|
|Formulation||lyophilized IgG with BSA|
Andreoletti O., Berthon P., Marc D., Sarradin P., Grosclaude J., Van Keulen L., Schelcher F., Elsen J-M., and Lantier F. (2000). Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie J.Gen Virol, 81, 3115-3126