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11?-Prostaglandin F2?

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    11?-<wbr/>Prostaglandin F<sub>2?</sub>
  • 11?-<wbr/>Prostaglandin F<sub>2?</sub>
Cat No: 16520
Biochemicals - Lipids
Cayman

11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces cont...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (5Z,9?,11?,13E,15S)-9,11,15-trihydroxy-prosta-5,13-dien-1-oic acid
Correlated keywords:
  • PGD 2 11 ? PGF 2 ? MCF7
Product Overview:
11β-Prostaglandin F2α (11β-PGF2α) is the primary metabolite of PGD2 (Item No. 12010).{57057} It is formed from PGD2 via the NADPH-dependent aldo-keto reductase PGF synthase (PGFS; Item No. 10007940) in the liver or lung.{57058} 11β-PGF2α induces contraction of isolated cat iris sphincter, which endogenously expresses high levels of PGF2α (FP) receptors, with an EC50 value of 0.045 µM.{57057} It also induces contraction of isolated human bronchial smooth muscle when used at concentrations ranging from 0.1 to 30 µM.{1756} 11β-PGF2α (0.1 and 1 µM) induces phosphorylation of ERK and CREB, as well as increases the viability of MCF-7 breast cancer cells stably expressing the FP receptor when used at concentrations of 0.1 and 1 µM.{57059}
Size 1 mg
Shipping dry ice
CAS Number 38432-87-0
Molecular Formula C20H34O5
SMILES O[C@@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C1
Molecular Weight 354,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2937.50
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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