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Cyclosporin A

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    Cyclosporin A
  • Cyclosporin A
Cat No: 12088
Biochemicals - Small Molecule Inhibitors
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM).{24989,20555,25125} It blocks the transcription of genes involved in T cell activation by interfering with...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • cyclosporin A
Correlated keywords:
  • antibiotics organs transplantations rejections cyclosporins A immunosuppressants immunosuppressive drugs nuclear factors activated T-cells NFAT transcription factors NF-AT IL-2 T cells calcineurin immunophilin transplants cyclosporine Debio088 088 debio equoral gengraf imusporin NSC 290193 NSCs 290193 NSC290193 neoplanta neural OL 27-400 OL27-400 optimmune papilock mini ramihyphin A restasis S-neoral SDZ-OXL 400 sandimmun neural optoral sandimmune sang-35 sang 35 sang35 sangCyA CyA sang-Cya sigmasporin microoral zinograf ME cyclophilin D inhibits inhibitions inhibitors phosphatase activity activities 55126-45-9 56645-58-0 104250-72-8 223528-56-1
Product Overview:
Cyclosporin A is an immunosuppressant drug that binds cyclophilin D, inhibiting the phosphatase activity of calcineurin in T cells (IC50 = 5 nM).{24989,20555,25125} It blocks the transcription of genes involved in T cell activation by interfering with the calcineurin-driven nuclear import of the transcription factor NFAT.{24989,21639,21213} Because of its powerful immunosuppressant activity, cyclosporin A has long been used for the prevention of transplant rejection.{25124}
Size 25 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 59865-13-3
Molecular Formula C62H111N11O12
SMILES O[C@@H]([C@](C(N[C@H](C(N(CC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@H]1CC(C)C)=O)=O)CC(C)C)=O)C)=O)CC)=O)([H])N(C([C@H](C(C)C)N(C([C@@H](N(C([C@H](CC(C)C)N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)=O)C)[C@H](C)C/C=C/C
Molecular Weight 1202,6
Formulation A white solid
Purity ≥99%
Custom Code 2921.29
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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