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15(S)-HETE ELISA Kit

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    15(S)-<wbr/>HETE ELISA Kit
  • 15(S)-<wbr/>HETE ELISA Kit
Cat No: 534721
Assay Kits - Elisa
Cayman
€356.00
Price is excluding VAT and does not include packaging neither shipping

15(S)-HETE is produced from arachidonic acid by the enzyme 15-lipoxygenase (15-LO). In humans it is formed primarily in the respiratory epithelium, leukocytes, and reticulocytes.{2363} 15(S)-HETE has been detected in high concentrations in nasal secre...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Technical Warning: Check the Additional Items Required section of this kit booklet to verify if UltraPure Water (Milli-Q or equivalent) is needed for this assay
Correlated keywords:
  • solid plates 15(S)-HETEs 15S-HETEs measures kits eias enzyme immunoassays ELISAs 15(S)HETEs 15HETEs assays ferroptosis
Product Overview:
15(S)-HETE is produced from arachidonic acid by the enzyme 15-lipoxygenase (15-LO). In humans it is formed primarily in the respiratory epithelium, leukocytes, and reticulocytes.{2363} 15(S)-HETE has been detected in high concentrations in nasal secretions and may contribute to allergic rhinitis.{373} 15(S)-HETE has anti-inflammatory properties, inhibiting carrageenan-induced arthritis and lowering leukotriene B4 (LTB4) concentrations in the synovial fluid of dogs.{1014} It may regulate T-lymphocytes by inhibiting 5- and 12-LOs.{682} It is also a vasoconstrictor, constricting cerebral and coronary arteries of dogs in vitro and cerebral arteries of pigs in vivo.{1015} 15(S)-HETE may also play a role in cancer, inhibiting apoptosis by carcinosarcoma cells.{3814} Our 15(S)-HETE ELISA is a competitive assay that permits the measurement of 15(S)-HETE within the range of 78-10,000 pg/ml, typically with a sensitivity (80% B/B0) of 185.4 pg/ml. This assay is very specific for 15(S)-HETE, showing very low crossreactivity to other HETEs.
Size 96 strip wells
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
Custom Code 3822.00
UNSPSC code 41116104

Pradelles, P., Grassi, J., and Maclouf, J.A. Enzyme immunoassays of eicosanoids using acetylcholinesterase as label: An alternative to radioimmunoassay. Anal Chem 57 1170-1173 (1985).

Ramis, I., Roselló-Catafau, J., Bulbena, O., et al. 15-Hydr

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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