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Ilimaquinone

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    Ilimaquinone
  • Ilimaquinone
Cat No: 15124
Biochemicals - Anti-Infection
Cayman
€190.00
Price is excluding VAT and does not include packaging neither shipping

Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties.{24002} In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory ...

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: 100 µg

This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 3-[[(1R,2S,4aS,8aS)-decahydro-1,2,4a-trimethyl-5-methylene-1-naphthalenyl]methyl]-2-hydroxy-5-methoxy-2,5-cyclohexadiene-1,4-dione
Correlated keywords:
  • 820243-60-5 natural products inhibitors inhibits inhibitions hypoxia antivirals antibiotics inflammation sesquiterpene quinones antimicrobials anti-microbial microbials anti anti-HIV antiHIV HIV anti-mitotic mitotic antimitotic anti-inflammatory inflammatory antiinflammatory golgi members anti-virals virals SAHs S-adenosylhomocysteine DNA Cdc25B ilimaquinone mammalian cells reversibly induces vesiculation membranes blocking blocks secretory pathways conversions S adenosylhomocysteine homocysteine hydrolases polymerases β B beta .beta. phosphatases genes expressions hypoxia-inducible factor-1 inducible factor 1
Product Overview:
Ilimaquinone is a natural sesquiterpene quinone that has antimicrobial, anti-HIV, anti-mitotic, and anti-inflammatory properties.{24002} In mammalian cells, 25 µM ilimaquinone reversibly induces vesiculation of Golgi membranes, blocking the secretory pathway.{24001,24000} It inhibits the conversion of S-adenosylhomocysteine (SAH) to homocysteine by SAH hydrolase (IC50 = 40 µM).{24002,24003} Ilimaquinone also inhibits DNA polymerase β and dual specificity phosphatase Cdc25B (IC50 = 45.2 and 92 µM, respectively) and, at 10 µM, activates gene expression through hypoxia-inducible factor-1.{24006,24004}
Size 100 µg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 71678-03-0
Molecular Formula C22H30O4
SMILES C=C1[C@@]2(C)CC[C@H](C)[C@](CC3=C(O)C(C=C(OC)C3=O)=O)(C)[C@]2([H])CCC1
Molecular Weight 358,5
Formulation A solid
Purity ≥98%
Custom Code 2932.99
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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