Atglistatin

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Atglistatin

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Cat No: 15284

Biochemicals - Small Molecule Inhibitors

Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, generating diacylglyerol.{21269,21272} Atglistatin is a potent, selective, and competitive inhibitor of AT...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N’-[4’-(dimethylamino)[1,1’-biphenyl]-3-yl]-N,N-dimethyl-urea

Correlated keywords:

inhibitors inhibits inhibitions obesity metabolic syndromes atherosclerosis diabetes metabolism PLPLA2 desnutrin adipose triglycerides lipases ATGL potent selective competitive blocks blockage blocking lipolysis in vitro whites tissues organs cultures in vivo catalyzes initial steps hydrolysis adipocytes non-adipocytes non lipids droplets diacylglyerol hormone-sensitive hormones sensitivemonoglyceride mono glycerides pancreatic lipoproteins lysophospholipases white knockout mice

Product Overview:
Adipose triglyceride lipase (ATGL or PNPLA2) catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets, generating diacylglyerol.{21269,21272} Atglistatin is a potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM).{24582} It does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases.{24582} Atglistatin blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo.{24582} It does not affect lipolysis in ATGL knockout mice.{24582}

Size	1 mg
Shipping	dry ice
CAS Number	1469924-27-3
Molecular Formula	C₁₇H₂₁N₃O
SMILES	CN(C)C1=CC=C(C2=CC(NC(N(C)C)=O)=CC=C2)C=C1
Molecular Weight	283,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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