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Protocatechuic Acid

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    Proto<wbr/>catechuic Acid
  • Proto<wbr/>catechuic Acid
Cat No: 14916
Biochemicals - Ox Stress Reagents
Cayman
€46.00
Price is excluding VAT and does not include packaging neither shipping

Protocatechuic acid (PCA) is a dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants. It is a major metabolite of antioxidant polyphenols found in green tea and demonstrates free radical scavenging capability in a 1,1-diphe...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 3,4-dihydroxy-benzoic acid
Correlated keywords:
  • phenolic acids antioxidants polyphenols anti-inflammatory antihyperglycemic neuroprotectives anticancers PCA dihydroxybenzoic medicinal plants metabolites green tea free radicals DPPH antiinflammatory anti inflammatory anti-hyperglycemic hyperglycemic anti-cancer cancers in vitro carcinogenesis pro-apoptotic anti-proliferative apoptotic proliferative tissues tumors cells mouse mice melanomas B16/F10 B16 F10 Ras Akt NF-κB NFκB NF.kappa.B kappa κ RhoB MMP NSC -16631 NSC16631
Product Overview:
Protocatechuic acid (PCA) is a dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants. It is a major metabolite of antioxidant polyphenols found in green tea and demonstrates free radical scavenging capability in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity assay (IC50 = 16.3 μM).{23837,23838} It is thought to possess anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities. Dietary administration of PCA dose dependently inhibits in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues.{23839} In studies of tumor cell migration and invasion using mouse melanoma B16/F10 cells, PCA at 0.1-2 mM down-regulated the Ras/Akt/NF-κB pathway by targeting RhoB activation, leading to a reduction of MMP-mediated activity.{23836}
Size 25 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 99-50-3
Molecular Formula C7H6O4
SMILES OC1=CC=C(C(O)=O)C=C1O
Molecular Weight 154,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.29
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : Proto<wbr/>catechuic Acid There are 7 products.

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