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Cat No: 10174
Biochemicals - Lipids

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilator...


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Territorial Availability: Available through Bertin Technologies only in France
  • (±)16,17-epoxy-4Z,7Z,10Z,13Z,19Z-docosapentaenoic acid
Correlated keywords:
  • epoxides epoxygenases cytochrome P450 (±)16,17-EpDPEs (+/-)16,17-EpDPEs fatty acids (+/-)16(17)EpDPEs 16(17)EETs eicosatrienoic neurochemistry 16,17-EDP 16,17EDP
Product Overview:
EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.{6485,7204} Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET (Item No. 50651) which are prime candidates for the actual active mediator.{5826} However, the CYP450 metabolites of eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310) have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.{11433}
Size 25 µg
Shipping dry ice
CAS Number 155073-46-4
Molecular Formula C22H32O3
Molecular Weight 344,5
Formulation A solution in ethanol
Purity ≥90%
Custom Code 2910.90
UNSPSC code 12352100

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