SC-51322

Confirm delete?

SC-51322

Zoom

Cat No: 10010744

Biochemicals - Receptor Pharmacology

The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 va...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8-chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide, dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid

Correlated keywords:

SC51322 SC 51322 prostaglandins E2 PGE2 receptors EP1 pain vasorelaxation inflammation PGs inflammatory signaling signalling antagonist Misoprostol, (11alpha,13Z)-(+-)-Isomer Misoprostol, (11beta,13E)-(+-)-Isomer Misoprostol (11alpha.13E,16S)-Isomer Misoprostol (11alpha,13E,16R)-Isomer Misoprostol, (11beta,13E,16S)-Isomer Misoprostol, (11beta,13E,16R)-Isomer Misoprostol (11alpha,13E)-Isomer Grunenthal Brand of Misoprostol Novopharm Brand of Misoprostol Misoprostol Grunenthal Brand Pfizer Brand of Misoprostol Misoprostol Novopharm Brand Apotex Brand of Misoprostol Misoprostol Pfizer Brand Misoprostol Apotex Brand Novo-Misoprostol Novo Misoprostol Apo-Misoprostol Apo Misoprostol Misoprostol SC-30249 SC-29333 SC 30249 SC 29333 SC30249 SC29333 Cytotec Glefos

Product Overview:
The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg.{10094} It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089.{10094} SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 µM.{16074}

Size	1 mg
Shipping	dry ice
CAS Number	146032-79-3
Molecular Formula	C₂₂H₂₀ClN₃O₄S
SMILES	ClC(C=C1)=CC2=C1OC3=CC=CC=C3CN2C(NNC(CCSCC4=CC=CO4)=O)=O
Molecular Weight	457,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.19
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.