SB-258585 (hydrochloride)

Biochemicals - Receptor Pharmacology

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Cat No: 17416

Biochemicals - Receptor Pharmacology

SB-258585 is a potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53).{30745} It displays over 100-fold selectivity for 5-HT6 over other 5-HT, dopamine, and α-adrenergic receptors. Radiolabeled forms of SB-258585 have been used to e...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-?iodo-?N-?[4-?methoxy-?3-?(4-?methyl-1-?piperazinyl)?phenyl]?-benzenesulfonamide, monohydrochloride

Correlated keywords:

209480-63-7 1173022-40-6 SB258585 5-HT6 5HT6 5HT-6 5-HT-6 5-hydroxytryptamine serotonin HCl

Product Overview:
SB-258585 is a potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53).{30745} It displays over 100-fold selectivity for 5-HT6 over other 5-HT, dopamine, and α-adrenergic receptors. Radiolabeled forms of SB-258585 have been used to evaluate other potential ligands of the 5-HT6 receptor.{29781} SB-258585 has been used in cells and in animals to evaluate the role of the 5-HT6 receptor in diverse processes.{30747,30744,30746}

Size	1 mg
Shipping	dry ice
CAS Number	1216468-02-8
Molecular Formula	C₁₈H₂₂IN₃O₃S • HCl
SMILES	CN(CC1)CCN1C2=C(OC)C=CC(NS(C3=CC=C(I)C=C3)(=O)=O)=C2.Cl
Molecular Weight	523,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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