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Hoechst 33258

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    Hoechst 33258
  • Hoechst 33258
Cat No: 16756
Cayman

Hoechst 33258 is a cell-permeable, benzimidazole dye that binds to the minor groove of double stranded DNA with preference for adenine and thymine-rich sequences.{22804} It emits blue fluorescence (excitation 352 nm/emission maximum 461 nm) when bound...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-phenol, trihydrochloride
Correlated keywords:
  • 23491-44-3 fluorescent dye stain probe supravital fluorescence DNA counterstain nuclear nuclei cell cycle apoptosis morphology biology indicator cell-permeable apoptotic hoechst33258 benzimidazole double stranded adenine thymine HOE33258 NSC322921
Product Overview:
Hoechst 33258 is a cell-permeable, benzimidazole dye that binds to the minor groove of double stranded DNA with preference for adenine and thymine-rich sequences.{22804} It emits blue fluorescence (excitation 352 nm/emission maximum 461 nm) when bound to DNA in either live or fixed cells and is useful as a marker of nuclei for cell cycle studies and to distinguish nuclear morphology in apoptotic cells.{27799,27800}
Size 50 mg
Shipping dry ice
CAS Number 23491-45-4
Molecular Formula C25H24N6O • 3HCl
SMILES CN1CCN(C2=CC(N=C(C3=CC(N=C(C4=CC=C(O)C=C4)N5)=C5C=C3)N6)=C6C=C2)CC1.Cl.Cl.Cl
Molecular Weight 533,9
Formulation A crystalline solid
Purity ≥95%
Custom Code 2933.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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