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Prostaglandin D2

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    Prostaglandin D<sub>2</sub>
  • Prostaglandin D<sub>2</sub>
Cat No: 12010
Biochemicals - Lipids
Cayman

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hyp...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 9?,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid
Correlated keywords:
  • Vasodilation prostaglandins brain sleep platelets aggregation. H-PGDS synthases mast cells hematopoietic allergic allergy asthmatic anaphylaxis hypotension inhibits inhibitors inhibition beta-trace .beta.-trace b-trace neurochemistry
Product Overview:
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes.{416} PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM.{1349}
Size 1 mg
Shipping dry ice
CAS Number 41598-07-6
Molecular Formula C20H32O5
SMILES CCCCCC(O)/C=C/[C@H]1C(=O)CC(O)C1C/C=C\CCCC(=O)O
Molecular Weight 352,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2937.50
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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