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Apocynin

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    Apocynin
  • Apocynin
Cat No: 11976
Biochemicals - Ox Stress Reagents
Cayman
€42.00
Price is excluding VAT and does not include packaging neither shipping

Apocynin is a compound isolated from the traditional medicinal plant P. kurroa and structurally related to vanillin that acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.{22116} Upon oxidation by myeloperoxi...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 1-(4-hydroxy-3-methoxyphenyl)-ethanone
Correlated keywords:
  • antioxidants NADPH oxidase superoxide O2- immunology inflammations arthritis atherosclerosis anti-inflammatory antiinflammatory inflammatory plants picrorhiza kurroa p. vanillin inhibitors inhibits inhibitions nicotinamide adenine dinucleotides phosphates reactive oxygen species ROS immune systems treatments arthritis bowl movements diseases asthma atherosclerosis familial amyotropic lateral sclerosis ALS oxidative injury natural immunology NSC2146 NSC-2146 NSC209524 NSC-209524 acetoguaiacon apocynine acetoguaicone
Product Overview:
Apocynin is a compound isolated from the traditional medicinal plant P. kurroa and structurally related to vanillin that acts as an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity.{22116} Upon oxidation by myeloperoxidase, apocynin inhibits the assembly of a functional NADPH-oxidase complex that is responsible for reactive oxygen species production.{22114,22115} At 300 μM it is effective in preventing the production of superoxide in human white blood cells or neutrophilic granulocytes, but does not however obstruct the phagocytic or other defense roles of granulocytes.{22116,22114,22115,22117} Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system. It has been used in the treatment of arthritis, bowel disease, asthma, atherosclerosis, and familial amyotrophic lateral sclerosis.{22116}
Size 1 g
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 498-02-2
Molecular Formula C9H10O3
SMILES CC(C1=CC(OC)=C(O)C=C1)=O
Molecular Weight 166,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2907.19
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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