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IL-17RA/CD217 Extracellular Domain (human, recombinant)

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    IL-17RA/CD217 Extracellular Domain (human, recombinant)
  • IL-17RA/CD217 Extracellular Domain (human, recombinant)
Cat No: 34632
Proteins - More Proteins
Cayman

IL-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that has roles in immunity and inflammation.{61785} It is composed of two extracellular fibronectin III-like domains that form the ligand-binding and receptor-dimerization domain,...

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: 10 µg

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • IL17 IL17RA CD-217 IL17E IL17F Trypanosoma IgG1Fc
Product Overview:
IL-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that has roles in immunity and inflammation.{61785} It is composed of two extracellular fibronectin III-like domains that form the ligand-binding and receptor-dimerization domain, a transmembrane domain, an SEF/IL-17R (SEFIR) domain, a TIR-like loop (TILL), and a C/EBPβ activation domain (CBAD). IL-17RA is ubiquitously expressed and localizes to the plasma membrane.{61786} It also exists as a soluble form that results from alternative splicing of IL17RA pre-mRNA. IL-17RA is involved in autoimmunity, neutrophil recruitment, and host defense.{61785} It forms a complex with IL-17RB, IL-17RC, or IL-17RE, each of which have varying affinities for the homodimeric ligands IL-17A, IL-17E, and IL-17F, and the IL-17A/IL-17F heterodimer.{61785,61787} Knockout of Il17ra increases mortality in mice infected with T. cruzi.{61788} In contrast, Il17ra-/- mice are protected against the development of collagen-induced arthritis.{61789} Mutations in IL17RA have been found in patients with chronic mucocutaneous candidiasis, a disease characterized by recurrent or persistent commensal Candida infections.{61790} Cayman's IL-17RA/CD217 Extracellular Domain (human, recombinant) protein can be used for binding assays. This protein is a disulfide-linked homodimer. The reduced monomer, composed of IL-17RA fused to AVI-tagged IgG1 Fc at its C-terminus, has a calculated molecular weight of 62 kDa. As a result of glycosylation, the monomer migrates at approximately 95 kDa by SDS-PAGE under reducing conditions.
Size 10 µg
Shipping dry ice
Formulation 8 mM phosphate buffer, pH 7.4, with 110 mM sodium chloride, 2.2 mM potassium chloride, and 20% glycerol
Purity ≥80% estimated by SDS-PAGE
Custom Code 3504.00
UNSPSC code 12352204

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